Atenolol nasal microspheres were prepared by using the emulsion cross linking technique. As the drug atenolol has 6-\r\n7 hrs half life it was formulated in the form of sustained release. Chitosan was used as polymer. Different cross linking agent\r\nglutaraldehyde and sodium tripolyphosphate were used in the preparations of microspheres. Among them sodium\r\ntripolyphosphate was found to be the better choice as the cross linking agent to attain the optimum result. Among the ratios\r\nprepared 1:3 ratio of core:coat is found to be the best ratio. The best formulation was selected on the basis of % entrapment\r\nefficiency and in-vitro drug release studies.
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